Functional Genomics

Program Overview

The Functional Genomics emphasis in the MS Genomics program prepares students to explore gene and genome function at the cellular and molecular level. All students complete a core curriculum covering modern genomics, including Script for Biologists, Genomics & Precision Medicine, Genomics Seminar I and II, Research in Progress I and II, Genomics Capstone, and Biomedical Research Ethics.

Functional Genomics students then focus on hands-on experimental coursework such as Advanced Cell Biology, Advanced Cell Culture, Stem Cell Biology, Genetic Engineering, Histology, and 3D Cell Culture. Capstone projects provide immersive research experiences using model systems like zebrafish, human cell cultures, and organoids. This combination of core and specialized training equips graduates with the skills and knowledge to study gene function, model disease, and drive innovations in biomedical research and biotechnology.

Application Requirements

• Specify your emphasis: Bioinformatics or Functional Genomics
• B.S. or B.A. in Biology, Biochemistry, Bioinformatics, Computer Science or closely related fields, from a regionally accredited institution (currently not accepting International students’ applications)
• 2 Letters of Recommendation (At least one from a Science Faculty Member)
• CV / Resume
• Official Transcripts
• Personal Statement (500–700 words)
• Minimum 3.0 GPA
• Completed Prerequisites:

Principles of Biology I – Utah Tech equivalent BIOL 1610, 4 credits

Fundamentals of Programming – Utah Tech equivalent CS 1400, 3 credits

Intro to Bioinformatics – Utah Tech equivalent BIOL 3300, 3 credits

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Why Zebrafish?

Zebrafish are a powerful and widely used model organism in genomics and biomedical research due to their unique combination of genetic, developmental, and practical advantages. They share a high degree of genetic similarity with humans, with many conserved genes and pathways involved in development and disease, making them highly relevant for studying gene function and human health. Their embryos are transparent and develop rapidly outside the body, allowing researchers to directly observe developmental processes in real time and assess the effects of genetic or environmental changes.

Zebrafish are also highly amenable to genetic manipulation techniques, including CRISPR-based gene editing, enabling precise investigation of gene function. In addition, they are cost-effective to maintain and produce large numbers of offspring, which supports high-throughput experimental design. Together, these features make zebrafish an ideal model for functional genomics studies, disease modeling, and drug discovery.

Why Organoids?

Organoids are an emerging and transformative research model in functional genomics, offering a three-dimensional, physiologically relevant system that more closely mimics the structure and function of human tissues than traditional cell culture. Derived from stem cells or primary tissues, organoids self-organize into complex cellular architectures that recapitulate key aspects of organ development, cellular diversity, and tissue-specific functions. This makes them particularly valuable for studying gene function, disease progression, and cell–cell interactions in a context that better reflects in vivo biology.

Organoids are also highly adaptable to genetic manipulation and can be generated from patient-derived cells, enabling personalized disease modeling and drug testing. By bridging the gap between simple cell lines and whole-organism models, organoids provide a powerful platform for advancing functional genomics, regenerative medicine, and precision therapeutics.